Application of Divide and Conquer Extended Genetic Algorithm to Tertiary Protein Structure of Chymotrypsin Inhibitor-2

Authors

A. Alfaro
M. Doan
John M. Finke, University of Washington TacomaFollow
M. Galdes
M. Zohdy

Publication Date

1-1-2006

Document Type

Article

Abstract

Determining the method by which a protein thermodynamically folds and unfolds in three-dimension is one of the most complex and least understood problems in modern biochemistry. Misfolded proteins have been recently linked to diseases including Amyotrophic Lateral Sclerosis and Alzheimer's disease. Because of the large number of parameters involved in defining the tertiary structure of proteins, based on free energy global minimisation, we have developed a new Divide and Conquer (DAC) Extended Genetic Algorithm. The approach was applied to explore and verify the energy landscape of protein chymotrypsin inhibitor-2.

Publication Title

Applied Bionics and Biomechanics

Volume

3

Issue

4

First Page

263

Last Page

271

DOI

10.1533/abbi.2006.0038

Publisher Policy

open access

Open Access Status

OA Journal

Recommended Citation

Alfaro, A.; Doan, M.; Finke, John M.; Galdes, M.; and Zohdy, M., "Application of Divide and Conquer Extended Genetic Algorithm to Tertiary Protein Structure of Chymotrypsin Inhibitor-2" (2006). SIAS Faculty Publications. 512.
https://digitalcommons.tacoma.uw.edu/ias_pub/512