Publication Date
2017
Document Type
Article
Abstract
This review serves to highlight approaches that may improve the access of antibody drugs to regions of the brain affected by Alzheimer's Disease. While previous antibody drugs have been unsuccessful in treating Alzheimer's disease, recent work demonstrates that Alzheimer's pathology can be modified if these drugs can penetrate the brain parenchyma with greater efficacy. Research in antibody blood-brain barrier drug delivery predominantly follows one of three distinct directions: (1) enhancing influx with reduced antibody size, addition of Trojan horse modules, or blood-brain barrier disruption; (2) modulating trancytotic equilibrium and/or kinetics of the neonatal Fc Receptor; and (3) manipulation of antibody glycan carbohydrate composition. In addition to these topics, recent studies are discussed that reveal a role of glycan sialic acid in suppressing antibody efflux from the brain.
Publication Title
Human Antibodies
Volume
25
Issue
3-4
First Page
131
Last Page
146
DOI
10.3233/HAB-160306
Publisher Policy
pre print, post print
Open Access Status
OA Deposit
Recommended Citation
Finke, John M. and Banks, William A., "Modulators of IgG Penetration Through the Blood-Brain Barrier: Implications for Alzheimer's Disease Immunotherapy" (2017). SIAS Faculty Publications. 825.
https://digitalcommons.tacoma.uw.edu/ias_pub/825
