Title
The Vanishing Zero Revisited: Thresholds in the Age of Genomics
Publication Date
5-19-2010
Document Type
Article
Abstract
The concept of the vanishing zero, which was first discussed 50 years ago in relation to pesticide residues in foods and food crops, focused on the unintended regulatory consequences created by ever-increasing sensitivity and selectivity of analytical methods, in conjunction with the ambiguous wording of legislation meant to protect public health. In the interim, the ability to detect xenobiotics in most substrates has increased from tens of parts per million to parts per trillion or less, challenging our ability to interpret the biological significance of exposures at the lowest detectable levels. As a result the focus of risk assessment, especially for potential carcinogens, has shifted from defining an acceptable level, to extrapolating from the best available analytical results. Analysis of gene expression profiles in exposed target cells using genomic technologies can identify biological pathways induced or repressed by the exposure as a function of dose and time. This treatise explores how toxicogenomic responses at low doses may inform risk assessment and risk management by defining thresholds for cellular responses linked to modes or mechanisms of toxicity at the molecular level.
Publication Title
Chemico-Biological Interactions
Volume
184
First Page
273
Last Page
278
DOI
10.1016/j.cbi.2010.01.031
Publisher Policy
pre print, post print (12 month embargo)
Recommended Citation
Zarbl, Helmut; Gallo, Michael A.; Yeung, Ka Yee; Glick, James; and Vouros, Paul, "The Vanishing Zero Revisited: Thresholds in the Age of Genomics" (2010). School of Engineering and Technology Publications. 297.
https://digitalcommons.tacoma.uw.edu/tech_pub/297